Who WAS the star who fled Gwyneth Paltrow’s home?

Mystery has gripped the Hamptons set – after a celebrity ‘on Ozempic’ reportedly lost control of their bowels in a bed in Gwyneth Paltrow‘s home.  

A party at the star’s holiday home took something of an embarrassing turn when an unnamed A-lister ‘using the wonder drug’ was allegedly forced to flee after leaving an unsightly mess in their bed.

Word of the mortifying incident is said to have quickly spread through Long Island’s exclusive enclave, sparking a guessing game over who the mystery guest could be.

Unable to face the consequences of the Ozempic-induced diarrhoea, the star reportedly snuck out of Paltrow’s sprawling home and headed back to New York City to hide in shame.

The medication, typically used to treat diabetes, has quickly become known as Hollywood’s ‘worst kept slimming secret’, allowing people to shed weight quickly.

Yet while the benefits of the jab have spread like wildfire in California and beyond, many have failed to relay the the common side-effect that affects one in 10 users.

The active ingredient of semaglutide not only triggers weight loss but causes gastrocolic reflex, which can lead to explosive and uncontrollable diarrhoea. 

The embarrassing ‘scandal’ was first reported in a weekly gossip magazine as a blind item.

It read: ‘Ozempic-induced diarrohea is becoming a very hot topic of conversation between hosts there — because so many of their guests are using it,’ the recent blind item claimed. So expect laundrettes to be fully booked from July 4.’

There are no suggestions that Paltrow herself has ever used or was using Ozempic or similar medication, only that a guest at her house might have experienced the unpleasant side-effects of the drug. 

MailOnline is also not suggesting that a celebrity named or pictured in this story is suffering or has ever suffered from the gastrointestinal side effect described in the Popbitch newsletter.

In recent months, a handful of celebrities have admitted to using the Ozempic, including Oprah Winfrey, Elon Musk, Sharon Osbourne, Chelsea Handler and Robbie Williams.

Amongst them is comedian Amy Schumer, who admitted taking the drug in 2022 but announced in June 2023 she had quit due to side effects. ‘I was one of those people who felt so sick,’ she said. 

Rebel Wilson shed 80lb in four years to reach her goal weight of 165lb (11st 8lb). She shed most of the excess in 2020, calling it her ‘year of health’, and putting it down to healthy eating and exercise.

However while promoting her memoir, Rebel Rising, she admitted to using Ozempic. The Pitch Perfect star, 44, says she used the drug briefly after she had lost weight, to help maintain her new shape.

She told The Sunday Times: ‘Someone like me could have a bottomless appetite for sweets, so I think those drugs can be good.’

Rebel says that she has since regained 20lb due to the stress surrounding the release of her controversial book.

Oprah Winfrey, 70, recently said that laughing about her weight became a national pastime in America.

Speaking on her programme Shame, Blame And The Weight Loss Revolution, she said: ‘I was ridiculed on every late-night talk show for 25 years and tabloid covers for 25 years.’

She admitted to trying fad diets, including a liquid- only one that resulted in a 67lb loss (which she quickly regained). In December, Winfrey — who gave up her job as an ambassador for WeightWatchers — admitted to using ‘weight loss medication’, telling People magazine: ‘The fact that there’s a medically approved prescription for managing weight and staying healthier, in my lifetime, feels like relief, like redemption, like a gift, and not something to hide behind and once again be ridiculed for. I’m done with the shaming.’

She has now reached her 160lb (11st 4lb) goal.

Weight loss drugs work by mimicking GLP-1, a hormone made naturally in the body that helps slow the passage of food through the stomach, in turn making people feel less hungry. 

It also alters the brain’s appetite regulation so that users feel satisfied despite eating less and they also don’t experience cravings for treat foods. 

Clinical trials show that 30 per cent of patients experience diarrohea on Wegovy, compared to 16 percent on the placebo, according to the drug’s prescribing information.

Common side effects of Ozempic include constipation, diarrhea, nausea, vomiting, and abdominal pain, according to the drug’s label.

Meanwhile, longer-term side-effects have also started to emerge.

Muscle loss is one key side effect after scientists looking into the GLP-1 drugs showed roughly 40 per cent of weight loss is muscle mass rather than fat.

This can have serious long term health impacts as not only are muscles needed to burn calories but for those who are middle-aged or elderly, muscle loss can lead to fragility or even early death.  

Less common complications of GLP-1 medications are gallstones, increased heart rate, kidney damage and pancreatitis — a condition where the pancreas rapidly becomes painfully inflamed.

Another serious concern is gastroparesis, a severe disorder where the stomach muscles become effectively paralysed and the stomach does not empty, and sufferers vomit days-old food. 

For some patients, the only remedy for gastroparesis may be a gastric bypass.

 Explosive Ozempic side effect ‘sweeping Hollywood’ that could affect more than one in ten patients, experts say

They’ve been dubbed Hollywood’s ‘worst kept slimming secret’. But for at least one celeb using jabs like Ozempic to stay slim, it has come at a mortifying social cost. 

An unnamed A-lister taking the medication apparently lost control of their bowls in bed, while staying overnight at the home of actress, and owner of wellness and lifestyle brand Goop, Gwyneth Paltrow.

The incident occurred ‘recently’ at the star’s property in the Hamptons, where affluent New York City residents typically descend for the summer, according to celeb gossip website Popbitch. 

It added that ‘Ozempic-induced diarrhoea is becoming a very hot topic’ in Hollywood as so many are on the drug.

However this unfortunate side effect is not confined to celebrity circles, with more than one in ten patients said to be affected.   

Ozempic contains the active ingredient semaglutide, and while classed as a diabetes medication, has been used by some people to lose weight.

The drug works by mimicking a hormone the body uses to tell us the stomach is full, and we should stop eating, helping suppress appetite and slowing overall digestion.

However, this can also trigger what is known medically as the gastrocolic reflex.

This essentially means the stomach sends a signal to the brain that because a large amount of food has been consumed room needs to be made further down the line. 

In consequence the colon and the rectum are instructed to empty their contents. 

But if the digestive process hasn’t been completed fully, which is more likely when the signal is artificial in the case of drugs like semaglutide, this can lead to explosive diarrhoea.

As Wegovy, the dedicated weight loss version of semaglutide, contains exactly the same ingredient people on this drug also carry the same risk.

Previous clinical trials showed that 30 per cent of patients experience diarrhoea on Wegovy, compared to 16 percent on the placebo.

Drug information leaflets distributed with Ozempic and Wegovy describe diarrhoea as a ‘very common’ side effect reported in more than one in 10 patients.

But they add this most commonly strikes when people first start on the drug and usually fades away over time as their body adjusts to the drug. 

Ozempic and Wegovy, made by the Danish pharma firm Novo Nordisk, belong to a class of drugs called GLP-1 agonists, named after the hormone they mimic. 

Rival drugs that work in a similar way such as Mounjaro, which contains the drug tirzepatide, are just as likely to cause the same side effect.

Online, jab users have also recounted their own digestive troubles while on the medications.

One, who shared their experience on the website Reddit wrote: ‘I quite literally s**t myself while sleeping. That’s a first.’

They added: ‘Been tough few days of diarrhoea after my first semaglutide injection.’ 

Another user, a 43-year-old anonymous man, on Wegovy said: ‘I just feel SO embarrassed being a grown adult who messed his pants!’

A different patient described being on their way to a birthday dinner but added how they ‘ended up s******g my pants probably 15 minutes into the drive.’

Digestive issues are an unsurprising consequence of many dedicated weight-loss medications even among non GLP-1 agonists. 

Orlistat, sold under the brand Xenical, has prescribed to people needing to lose weight on the NHS for years.

This drug works by physically preventing fat from being absorbed in the gut and instead keeping it locked in faeces which are then passed out through the body.

The disruption to the normal digestive process can likewise result in patients experiencing diarrhoea, oily or fatty faeces or oily discharge from the back passage, dubbed anus ‘anal seepage’ 

Patients experiencing diarrhoea while on weight-loss drugs can do very little to stop the effect, though some take drugs like loperamide, sold under the brand name Imodium, in attempt to combat the symptoms.

People experiencing diarrhoea in general are advised to avoid eating food and drinks that can exacerbate digestive issues or act as natural laxatives by the NHS. 

These include high-fibre foods, fruit juice, nuts and dried fruits, uncooked vegetables and fruit, beans, lentils and pulses, cauliflower, cabbage and onions, spicy or fatty foods, as well as alcohol, strong tea and coffee.